Ventilator-associated pneumonia (VAP). Unspecified bacterial pneumonia
Conditions
Interventions
Intervention 1: Intervention group 1: The colistin nebulizer group will receive a dose of 2,000,000 units diluted in 2.5 mL of normal saline, administered three times a day for three days. Interventio
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients (18 or above) Who has been under invasive mechanical ventilation for at least 48 hours
Exclusion criteria
Exclusion criteria: Patients who have been under mechanical ventilation for at least 120 hours. They are suspected or confirmed to have VAP Suffering from acute kidney injury, chronic kidney failure (glomerular filtration rate <30 ml per minute) Having a tracheostomy tube ?Extubation within the next 24 hours Patients with evidence of aminoglycoside resistance in their blood or tracheal culture antibiogram report. History of any occurrence of myasthenia gravis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of ventilator-associated pneumonia (VAP). Timepoint: The 14-day period following the initiation of inhaled antibiotics. Method of measurement: In the event of any suspected symptoms of pneumonia, tracheal secretion aspiration samples will be collected from the patients. Information will be obtained from patients either in person or via phone call if they have been discharged. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: 14 days from the initiation of antibiotic therapy. Method of measurement: Patients' follow-up.;Duration of mechanical ventilation. Timepoint: Up to 14 days from the initiation of antibiotic therapy. Method of measurement: Patients' follow-up. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammadreza Salehi
Tehran University of Medical Sciences
Outcome results
None listed