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"The effectiveness of dextrose prolotherapy in knee osteoarthritis"; "The effectiveness of genicular nerve block in knee osteoarthritis"

The comparison of the effectiveness of dextrose prolotherapy vs. genicular nerve block in reducing pain and improving function in patients with knee osteoarthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201013049018N1
Enrollment
30
Registered
2021-04-07
Start date
2021-05-20
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Intervention 1: Intervention group: The group undergoing the block of three branches of the genicular sensory nerves (supramedial, supralateral and inframedial branches) in one session (common techniq

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 70 Years

Inclusion criteria

Inclusion criteria: Existence of pain and other clinical signs of knee osteoarthritis and pain with a VAS score of at least 4 due to knee osteoarthritis during last month Age between 45 to 70 years old Absence of any periarticular disease around the target joint

Exclusion criteria

Exclusion criteria: Diabetes Mellitus Rheumatologically and collagen vascular disorders (eg; gout and lupus) Radiculopathy Nerve injuries and neuropathy Brucellosis BMI more than 42 Knee replacement on the affected side History of trauma and joint fracture Severe deformity of the lower extremities Bleeding disorders Inability to communicate History of allergic reactions to the used drugs History of intraarticular or periarticular injections at the affected joint in the last 3 months History of significant liver, kidney and cardiopulmonary disorders Pregnancy Malignancy Use of anticoagulants

Design outcomes

Primary

MeasureTime frame
Pain due to knee osteoarthritis. Timepoint: Before starting the intervention; 2, 4, 8, &12 weeks later. Method of measurement: Visual analog scale; Western Ontario and McMaster Universities Arthritis Index; Oxford knee scale; Patient satisfaction.

Secondary

MeasureTime frame
Patient function. Timepoint: Before starting the intervention; 2, 4, 8, &12 weeks later. Method of measurement: Visual analog scale.;Patient function. Timepoint: Before starting the intervention; 2, 4, 8, &12 weeks later. Method of measurement: Western Ontario and McMaster Universities Arthritis Index.;Patient function. Timepoint: Before starting the intervention; 2, 4, 8, &12 weeks later. Method of measurement: Oxford knee scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Esmaeil Ghorbani Nejad

Shiraz University of Medical Sciences

m_ghorbani1990@yahoo.com+98 71 3639 6445

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026