Investigating the effect of Lidocaine injection into the airways in order to prevent lung infection

Investigating the effect of Lidocaine injection into tracheal lumen in order to prevent pulmonary infection in trauma patients under mechanical ventilation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201013049017N2

Enrollment

Registered

2022-09-15

Start date

2022-08-27

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary infection. Unspecified bacterial pneumonia

Interventions

Intervention 1: Intervention group: 1 mg per kilogram of body weight of 2% lidocaine without epinephrine will be injected into the tracheal lumen 3 times a day for 72 hours by the project manager. On

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Being under mechanical ventilation for more than three days Consent of first-degree relative for participating in the study

Exclusion criteria

Exclusion criteria: Receiving broad-spectrum antibiotics (Fluoroquinolones, 3rd and 4th generation Cephalosporins, Carbapenems, Tazocin and other broad-spectrum antibiotics) within 72 hours before the intervention Pulmonary disease(Asthma/COPD) History of cardiac rhythm or rate disorders

Design outcomes

Primary

Measure	Time frame
Pulmonary infection according to laboratory culture samples. Timepoint: before the start of the intervention and 72 hours after the start of the intervention. Method of measurement: Cultivation of pulmonary secretions in laboratory.	—

Secondary

Measure	Time frame
Extubation time. Timepoint: After the end of the intervention (After 72 hours). Method of measurement: Extubation date.;Time of discharge from ICU. Timepoint: After the end of the intervention (After 72 hours). Method of measurement: Date of discharge from ICU.;Average CRP level. Timepoint: Before the intervention and 72 hours after the intervention. Method of measurement: CRP test.;Average ESR level. Timepoint: Before the intervention and 72 hours after the intervention. Method of measurement: ESR test.;Average Hemoglobin level (Hb). Timepoint: Before the intervention and 72 hours after the intervention. Method of measurement: Complete blood count test results.;Average White blood cell level (WBC). Timepoint: Before the intervention and 72 hours after the intervention. Method of measurement: Complete blood count test results.	—

Measure

Time frame

Extubation time. Timepoint: After the end of the intervention (After 72 hours). Method of measurement: Extubation date.;Time of discharge from ICU. Timepoint: After the end of the intervention (After 72 hours). Method of measurement: Date of discharge from ICU.;Average CRP level. Timepoint: Before the intervention and 72 hours after the intervention. Method of measurement: CRP test.;Average ESR level. Timepoint: Before the intervention and 72 hours after the intervention. Method of measurement: ESR test.;Average Hemoglobin level (Hb). Timepoint: Before the intervention and 72 hours after the intervention. Method of measurement: Complete blood count test results.;Average White blood cell level (WBC). Timepoint: Before the intervention and 72 hours after the intervention. Method of measurement: Complete blood count test results.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParisa Karimian

Esfahan University of Medical Sciences

karimian_P75@yahoo.com+98 31 3624 9973

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026