Treatment of Helicobacter pylori infection of the stomach

Eradication Efficacy of high dose amoxicillin and PPI Compared with standard bismuth containing quadruple Therapy as a First Line Treatment of Helicobacter pylori

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201007048956N1

Enrollment

220

Registered

2020-11-09

Start date

2019-08-25

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

helicobacter pylori infection. Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere

Interventions

Intervention 1: Intervention group: amoxicillin 750mg QID and pantoprazole 40mg TDS for 14 days. Intervention 2: Control group:Bismuth containing Quadruple thrapy{ clarithromycin 500 mg and amoxicill

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: chronic gastritis with or without healed duodenal or stomach ulcer H. pylori positive determined by Rapid UreaseTest or Urea Breath Test treatment-naive patients for eradication of H. pylori infection

Exclusion criteria

Exclusion criteria: allergy to medications used in this clinical trial use of PPI, histamine H2-receptor antagonists, antibiotics, bismuth, or probiotics 4 weeks before initiating study pregnancy or breastfeeding

Design outcomes

Primary

Measure	Time frame
Helicobacter pylori infection. Timepoint: 45 days after intervention. Method of measurement: stool antigen test of helicobacter pylori.	—

Secondary

Measure	Time frame
Reduce the cost of treatment. Timepoint: 45 days. Method of measurement: Lower cost.;Less drug side effects. Timepoint: 45 days. Method of measurement: Patient clinical sign.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmin Sabbaghan

Ahvaz University of Medical Sciences

Sabbaghanamin@yahoo.com+98 61 3336 0421

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026