Effect of intralesional Mitomycin-C and Triamcinolone on reducing the urethral stricture recurrence

Comparison between the effect of intralesional Mitomycin-C and Triamcinolone on reducing the urethral stricture recurrence in patients undergoing internal urethrotomy surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201006048950N4

Enrollment

100

Registered

2024-03-04

Start date

2024-02-20

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urethral stricture.

Interventions

Intervention 1: Intervention group: The rate of recurrence of urethral stricture. Intervention 2: Control group: The rate of recurrence of urethral stricture.

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: The gender is male. have Bulbomembranous or a history of it History of radiotherapy History of radical prostatectomy and open prostatectomy

Exclusion criteria

Exclusion criteria: Have a history of once or twice internal ureterotomy Suffering from cancer of the prostate, bladder and urethra Urethral stricture more than 15 mm Suffering from BXO (Balinitis xerotica Obliterans) Have a history of straddle injury

Design outcomes

Primary

Measure	Time frame
Comparison between the effect of intralesional Mitomycin-C and Triamcinolone on reducing the urethral stricture recurrence in patients undergoing internal urethrotomy surgery. Timepoint: The injection of Mitomycin C and Triamcinolone are injected into the urethra in groups in five sessions. These injections are given daily in the first week, every other day in the second week, and then twice a week for two months. Method of measurement: After the interventions, the symptoms of Urethral Sound Dilator (USD) in patients will be evaluated based on the QoL (Quality of life) and IPSS (The International Prostate Symptom Score) questionnaires, as well as uroflowmetry test.	—

Measure

Time frame

Comparison between the effect of intralesional Mitomycin-C and Triamcinolone on reducing the urethral stricture recurrence in patients undergoing internal urethrotomy surgery. Timepoint: The injection of Mitomycin C and Triamcinolone are injected into the urethra in groups in five sessions. These injections are given daily in the first week, every other day in the second week, and then twice a week for two months. Method of measurement: After the interventions, the symptoms of Urethral Sound Dilator (USD) in patients will be evaluated based on the QoL (Quality of life) and IPSS (The International Prostate Symptom Score) questionnaires, as well as uroflowmetry test.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRasoul Jafari

Arak University of Medical Sciences

amozesh@arakmu.ac.ir+98 86 3383 8602

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026