Evaluation of the effect of memantine for the prevention of headaches caused by head trauma

Evaluation of prophylactic effect of memantine in comparison with placebo on post-traumatic headache in patients with head trauma 3 months and 6 months after starting the drug

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201005048944N1

Enrollment

Registered

2021-01-11

Start date

2020-08-22

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post traumatic headache. post traumatic headache

Interventions

Intervention 1: Intervention group: Memantine tablets are an N-methyl-D-aspartate (NMDA) receptor-dependent inhibitor of the glutamate receptor subtype.For patients in the intervention group, 10 mg o

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: People who have head trauma

Exclusion criteria

Exclusion criteria: Having a history of severe neurological disease Having a history of severe mental illness Having brain complications from trauma such as infections

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 3 months and 6 months after treatment. Method of measurement: Visual Analogue Scale questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactelham bani

Esfahan University of Medical Sciences

bani@resident.mui.ac.ir+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026