Condition 1: chronic kidney disease. Condition 2: uremic pruritus. Chronic kidney disease (CKD) Pruritus, unspecified
Conditions
Interventions
Intervention 1: Intervention group:Lactiplantibacillus plantarum group: Oral medication in the form of drops equivalent to CFU=1*109 of Lactiplantibacillus plantarum bacteria administered daily for 12
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years Continuous hemodialysis for more than three months They should have suffered from itching for at least 6 weeks.
Exclusion criteria
Exclusion criteria: Liver disease History of seizures Skin disease associated with itching Hemolytic blood disease First complaint of itching Use of any type of antibiotic Participation in another clinical trial in the past month pregnancy active cancer Active infection Sensitivity to probiotic compounds
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uremic pruritus( method of Scale Analogue Visual and the Persian version of the 5-Scale Itching Questionnaire). Timepoint: At the beginning of the study (before the intervention starts), during the intervention (6 weeks after the intervention starts), and after the intervention (immediately after 12 weeks from the start of the intervention). Method of measurement: To assess itching, the Scale Analogue Visual method and the Persian version of the 5-Scale Itching Questionnaire, whose validity and reliability have been confirmed by Yousef Nejad, will be used. | — |
Secondary
| Measure | Time frame |
|---|---|
| C-REACTIVE PROTEIN. Timepoint: At the beginning of the study (before the intervention starts) and at the end of the intervention (after completing 12 weeks). Method of measurement: ELISA.;Interlukine-6. Timepoint: At the beginning of the study (before the intervention starts) and at the end of the intervention (after completing 12 weeks). Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahboobe Rastgoo
Shiraz University of Medical Sciences
Outcome results
None listed