Effect of biotin, brewer’s yeast and vitamin C supplements in patients with COVID-19

Investigation of simultaneous administration of biotin, brewer’s yeast, and vitamin C supplements on the improvement of clinical symptoms in patients with COVID-19

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20201004048923N1

Enrollment

Registered

2020-12-13

Start date

2020-10-15

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronavirus disease 2019 (COVID-19). U07. 1

Interventions

Intervention 1: Intervention group: Patients in this group, addition to their routine treatment will receive

first day: two biotin tablets (5000 micrograms) simultaneously and after that with at least 6 hours, one another biotin tablet (5000 micrograms), second and third days: two biotin tablets (5,000 micr

Eligibility

Sex/Gender

Male

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age between 20 to 60 years old Male sex COVID-19 patients with positive chest CT scan

Exclusion criteria

Exclusion criteria: Infectious diseases, cancer and autoimmune diseases Severe heart and liver diseases Existence of severe clinical symptoms that require hospitalization Diabetes

Design outcomes

Primary

Measure	Time frame
Clinical symptoms improvement. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.	—

Secondary

Measure	Time frame
Fever. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Chills. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Fatigue. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Cough. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Shortness of breath. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Headache. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Myalgia. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Earache. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement	—

Measure

Time frame

Fever. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Chills. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Fatigue. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Cough. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Shortness of breath. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Headache. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Myalgia. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement: Patient statements during the phone call and recording information according to the scoring system designed in the checklist.;Earache. Timepoint: At the beginning of the study (before the intervention) and after receiving supplements, daily. Method of measurement

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Maliheh Paknejad

Tehran University of Medical Sciences

paknejadma@tums.ac.ir+98 21 6405 3295

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026