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Mirtazapine Augmentation in Resistant Obsessive Compulsive Disorder

Mirtazapine Augmentation in Resistant Obsessive Compulsive Disorder:a Double Blind Placebo Controlled Clinical Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20201004048919N1
Enrollment
60
Registered
2021-05-11
Start date
2021-07-21
Completion date
Unknown
Last updated
2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive -compulsive disorder. Obsessive-compulsive disorder

Interventions

Intervention 1: Sertraline tablets at a dose of 100-300 mg per day (depending on patient tolerance) with 7.5 to 30 mg of mirtazapine daily for 12 weeks as an intervention group. Intervention 2: Sertra

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: people who have been diagnosed with obsessive -compulsive disorder based on DSM5. People with a yale-brown obsessive compulsive scale above 15. Has an age range of 18 to 60 years.

Exclusion criteria

Exclusion criteria: Pregnant women and breastfeeding People receivinig psychotherapy. having major physical illnesse: liver problems (they have high liver enzymes),kidney problems(BUN ,CR are high), thyroid problem, trouble breathing. They have other psychiatric problems: According to the DSM5 criteria, they have psychotic disorder, anxiety disorder, dementia, mood disorder, and mental retardation. use drugs or alcohol

Design outcomes

Primary

MeasureTime frame
The severity of the symptoms of obsessive -compulsive disorder. Timepoint: The beginning of the study and 2-4-6-8-12 weeks after the start of treatment. Method of measurement: Based on the questionnaire Y-BOCS.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHaniyeh baniasadipour

Shiraz University of Medical Sciences

h.baniasadipour@yahoo.com+98 71 3647 9531

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026