Condition 1: Patients with recurrent implantation failure. Condition 2: Patients with recurrent implantation failure. Complications of attempted introduction of fertilized ovum following in vitro fertilization Female infertility of uterine origin
Conditions
Interventions
Intervention 1: Intervention group: this study attempts to explore and assess 178 infertile further three recurrent implantation failures. This group will receive the growth hormone produced by Cinna
Sponsors
Avicenna Reseacrh Institute
CinnaGen company
Eligibility
Sex/Gender
Female
Age
22 Years to 39 Years
Inclusion criteria
Inclusion criteria: have a history of more than two previous unexplained IVF failures (3=)(despite transfer of minimum one good grade A blastocyst embryo) , no previous hormone growth cycle, no other interventions in this cycle(hystroscopy and Imunomodolator drugs ), no donation cycle, no hormone contraindications, not having hydrosalpinx, , having at least one good grade A blastocyst freezed embryo for transfer , FSH=10, AMH=1.8
Exclusion criteria
Exclusion criteria: Age= 40 years, BMI=30, endometriosis, severe oligospermia, (Sperm count 500) and autoimmune diseases and local allergic reactions and benign increase in intracranial pressure, submucosal myoma, metabolic syndrome, sex selection , karyotype disorder, uterian anomalis, Synechsia, Hx of thin enodmetrium(endometrial line<7mm) , no patient consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy rate. Timepoint: 5-6 weeks after taking the drug. Method of measurement: The number of patients with positive gestational sac divided by the number of patients who had embryo transfer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial receptivity. Timepoint: 2 weeks after taking the drug. Method of measurement: measurement of sub endometrial flow by power Doppler sono and endometrial volume and thickness by 3D and 2D ultrasonograghy.;Chemical pregnancy rate : the rate of positive pregnancy test 2 weeks after embryo transfer. Timepoint: 2 weeks after embryo transfer. Method of measurement: evaluation of positive pregnancy test after transfer of blastocyst (s) embryo(s).;Implantation rate. Timepoint: measurement of number gestational sac divided by number of blastocyst embryo transfer. Method of measurement: evaluation of positive and number of intrauterine gestational sac after transfer of blastocyst (s) embryo(s) by ultrasonograghy.;Live birth rate : number of delivery of viable fetuses(more than 28 weeks) divided by number of embryo transferred. Timepoint: Gestational age more than 28 weeks of pregnancy. Method of measurement: Delivery of viable fetuses after 28 after pregnancy. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mina Ataei
Avicenna Infertility Center
Outcome results
None listed