Therapeutic Efficacy of Urtica dioica and Evening Primrose in Patients with Rheumatoid Arthritis: A Randomized Double-Blind, Placebo-Controlled Clinical Trial.
Conditions
Interventions
Intervention group 1: Magnolia evening primrose 400 mg capsule Intervention group 2: Nettle capsule Nettle capsule 400 mg Control group: placebo 500 mg capsule for three months three times a day Barij
Sponsors
Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: RA was diagnosed according to the revised 2010 American College of Rheumatology (ACR) criteria
Exclusion criteria
Exclusion criteria: Patients with cardiovascular disease Patients with respiratory diseases Patients with renal disease Patients with liver disease Patients under sex hormone therapy Use supplements before the intervention Changing the treatment of RA patients Allergy to nettle Patients with other inflammatory diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DAS28 (Disease Activity Score) The DAS28 is a measure of disease activity in rheumatoid arthritis (RA). DAS stands for 'disease activity score', and the number 28 refers to the 28 joints that are examined in this assessment. Timepoint: Disease Activity Score 28 is measured at the beginning of the study (before the start of the intervention) and at the end of the study (3 months after the start of herbal medicine, nettle or evening primrose, and placebo). Method of measurement: The Disease Activity Score 28 is most easily calculated using a programmed calculator or a computer. Online and downloadable calculators are freely available at http://www.das-score.nl. | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythrocyte sedimentation rate (ESR) is a test that indirectly measures the degree of inflammation present in the body. The test actually measures the rate of fall (sedimentation) of erythrocytes in a sample of blood that has been placed into a tall, thin, vertical tube. Timepoint: Erythrocyte sedimentation rate measured at the beginning of the study (before the start of the intervention) and at the end of the study (3 months after the start of herbal medicine, nettle or evening primrose, and placebo). Method of measurement: Western Green is a method for estimating the sedimentation rate of red blood cells in whole blood by mixing venous blood with an aqueous solution of sodium citrate and allowing the mixture to stand in an upright standard pipet and, after one hour, reading the millimeters the cells have descended.;DAS28 (Disease Activity Score) The DAS28 is a measure of disease activity in rheumatoid arthritis (RA). DAS stands for 'disease activity score', and the number 28 refers to the 28 joints that are examined in this assessment. Timepoint: Disease Activity Score 28 is measured at the beginning of the study (before the start of the intervention) and at the end of the study (3 months after the start of herbal medicine, nettle or evening primrose, and placebo). Method of measurement: The Disease Activity Score 28 is most easily calculated using a programmed calculator or a computer. Online and downloadable calculators are freely available at http://www.das-score.nl.;Visual Analogue Scale (VAS) The visual analog scale is a validated, subjective measure for acute and chronic pain. Timepoint: Visual Analogue Scale is measured at the beginning of the study (before the start of the intervention) and at the end of the study (3 months after the start of herbal medicine, nettle or evening primrose, and placebo). Method of measurement: Visual Analogue Scale scores are recorded by making a handwritten | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBahareh Abd-Nikfarjam
Qazvin University of Medical Sciences
Outcome results
None listed