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The Effect of Combination of Micro-osteoperforation and a Vibration Device on Inflammatory Factors

The Effect of Combination of Micro-osteoperforation and a Vibration Device on Inflammatory Factors IL-1ß, RANKL, CCL2, and TNF-a in Orthodontic Tooth Movement: A Prospective Randomized Clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200928048869N1
Enrollment
20
Registered
2020-11-05
Start date
2020-11-21
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orthodontic treatment.

Interventions

Intervention 1: Intervention group receives MOPs on both sides (right and left) of the maxilla using a C-shaped vibrating device (Vpro5, Propel Orthodontics). Intervention 2: Control group: Receives M

Sponsors

Dental Research Institute of Tehran University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: age between 18-45 erupted canines need for extraction first maxillary premolars at least 3 mm space after initial alignment good oral hygiene

Exclusion criteria

Exclusion criteria: systematic disease which have effect on bone metabolism taking medication periodontal disease smoking pregnancy

Design outcomes

Primary

MeasureTime frame
Increased expression of inflammatory factors(IL-1ß, RANKL, CCL2 and TNF-a) following the use of vibration in orthodontic patients who received MOP. Timepoint: immediately before canine retraction, 24 hours later, 7 days later, and 28 days later. Method of measurement: ELISA kit.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanane Ghadirian

Tehran University of Medical Sciences

Dr.h.ghadirian@gmail.com+98 21 4279 4500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026