Drug use disorder. Opioid abuse with other opioid-induced disorder
Conditions
Interventions
Intervention 1: Intervention group: Transcranial Direct Current Stimulation (tDCS) is performed 2 times a day for 5 consecutive days. Stimulation is performed twice in the intervention group for 13 mi
Sponsors
Shahroud University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Subjects have to be male Subject who is right-handed Subject whose age is between 18 to 55 years At least the fifth elementary education Have opioid dependence criteria based on DSM-5 criteria Have no other psychiatric or neurological illness The main substance consumption have to be opium Do not consume other substances during the project Subject consents to participation in the study and provides a signed informed consent form
Exclusion criteria
Exclusion criteria: Contraindications to tDCS include the presence of any type of cerebral injury in the brain and metal plates on the head, chronic skin problems, severe reactions to tDCS in previous treatments, history of seizures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of changes in baseline substance craving and cue-induced craving. Timepoint: Before the intervention and after the intervention (fifth day) and 2 months later. Method of measurement: Visual Analog Scale, Desire for Drug Questionnaire, Obsessive-Compulsive Drug Use Scale.;Serum level changes of Brain-Derived Neurotrophic Factor. Timepoint: Before the intervention and after the intervention (fifth day). Method of measurement: Enzyme-Linked Immunosorbent Assay(ELISA).;Evaluation of changes in short-term memory and working memory. Timepoint: Before the intervention and after the intervention (fifth day) and 2 months later. Method of measurement: Forward & Backward Digit span Test.;Evaluation of changes in response inhibition and impulsivity. Timepoint: Before the intervention and after the intervention (fifth day) and 2 months later. Method of measurement: Go-No Go Test.;Evaluation of changes in decision making and risk-taking. Timepoint: Before the intervention and after the intervention (fifth day) and 2 months later. Method of measurement: Balloon Analog Risk Task (BART). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRoghieh Bahareh Borzooee
Shahroud University of Medical Sciences
Outcome results
None listed