The effect of platelet-rich fibrin on neurosensory recovery of inferior alveolar nerve injury

The effect of platelet-rich fibrin on neurosensory recovery of inferior alveolar nerve injury after mandibular body fracture

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200922048799N2

Enrollment

Registered

2022-01-10

Start date

2022-02-18

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inferior Alveolar nerve neurosensory defect due to mandibular body fracture. Injury of trigeminal nerve

Interventions

Intervention 1: Intervention group: Before the fixation of the fracture, the PRF will be put on the IAN of one side as the treatment group. Intervention 2: Control group: The fixation of the fracture

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients with bilateral mandibular body fracture with less than 5mm displacement, who are candidates for open reduction-internal fixation (ORIF)

Exclusion criteria

Exclusion criteria: Patients with other types of fracture or those who are not a candidate for the ORIF treatment method History of mandible genioplasty or orthognathic surgery History of mandible trauma History of mandibular fracture Obvious perioperative nerve injury Psychiatric medication Refusing to participate in the postoperative examinations Having neuropathic systemic diseases such as diabetes Having no consent for participation in the study

Design outcomes

Primary

Measure	Time frame
The two-point discrimination test (TPD). Timepoint: before the surgery (T0), 6 months after the surgery (T1), and 12 months after the surgery (T2). Method of measurement: the minimum distance of two discriminable points, which is created by a needle on the lower lip and the mental area.;The brush directional stroke discrimination test. Timepoint: before the surgery (T0), 6 months after the surgery (T1), and 12 months after the surgery (T2). Method of measurement: performed by movement of a thin brush on the lower lip and the mental area and the patient must recognize the direction of the brush movement.;Self reported paresthesia. Timepoint: before the surgery (T0), 6 months after the surgery (T1), and 12 months after the surgery (T2). Method of measurement: using the visual analogue scale with a score range of (1-10) so that scores of (1 to 3), (4 to 6), and (7-10) are defined as mild, moderate, and severe, respectively.	—

Measure

Time frame

The two-point discrimination test (TPD). Timepoint: before the surgery (T0), 6 months after the surgery (T1), and 12 months after the surgery (T2). Method of measurement: the minimum distance of two discriminable points, which is created by a needle on the lower lip and the mental area.;The brush directional stroke discrimination test. Timepoint: before the surgery (T0), 6 months after the surgery (T1), and 12 months after the surgery (T2). Method of measurement: performed by movement of a thin brush on the lower lip and the mental area and the patient must recognize the direction of the brush movement.;Self reported paresthesia. Timepoint: before the surgery (T0), 6 months after the surgery (T1), and 12 months after the surgery (T2). Method of measurement: using the visual analogue scale with a score range of (1-10) so that scores of (1 to 3), (4 to 6), and (7-10) are defined as mild, moderate, and severe, respectively.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Moslemi

Shahid Beheshti University of Medical Sciences

hmoslemi71@gmail.com+98 21 4044 3580

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026