Multiple sclerosis- MS. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: Probiotic capsule (Tak Gene Zist, Iran) contains Lactobacillus rhamnosus, Lactobacillus ruteri, Lactobacillus acidophilus, Lactobacillus paracasei, Bacillus coagula
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age range of 18 to 80 years, Capacity for signing the written informed consent Diagnosis of idiopathic Parkinson's disease based on the diagnostic criteria of the Brain Bank of Britain
Exclusion criteria
Exclusion criteria: Women who have been pregnant or lactating for the past 6 months Patients with a history of kidney stones over the past 5 years Postmenopausal women with irregular menstruation and unwillingness to use appropriate contraceptive tools Incidence of attack during the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Gastrointestinal Symptom Rating Scale (GSRS). Timepoint: Beginning of study and week 12. Method of measurement: questionnaire.;Beck anxiety inventory. Timepoint: Beginning of study and week 12. Method of measurement: questionnaire.;Unified Parkinson's Disease Rating Scale (UPDRS). Timepoint: Beginning of study and week 12. Method of measurement: questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum analyses (Level of IFN-?, IL-1ß, IL-6, IL-10, TNF-a, TAC and MDA). Timepoint: At the beginning of the study and week 12. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehran Ghaffari
Shahid Beheshti University of Medical Sciences
Outcome results
None listed