parkinson. Parkinson's disease
Conditions
Interventions
Intervention 1: Intervention group: probiotic capsule (Tak Gene Zist, Iran) containing L. rhamnosus, L. plantarum, L. acidophilus, L. salivarius, B. coagulans, B. longum ,vitamin D3 (400IU), magnesium
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age over 18 and under 80 Diagnosis of idiopathic Parkinson's disease based on UK PD Society Brain Bank criteria Using l-dopa or dopaminergic agonist
Exclusion criteria
Exclusion criteria: Use of systemic antibiotics, antifungals, antivirals or antiparasitics (intravenous, intramuscular, or oral) Use of commercial probiotics: includes tablets, capsules. Major surgery of the GI tract, with the exception of cholecystectomy and appendectomy, in the past five years History of active uncontrolled gastrointestinal disorders or diseases including: inflammatory bowel disease (IBD) including ulcerative colitis (mild-moderate-severe), Crohn's disease (mild-moderate-severe), or indeterminate colitis Infectious gastroenteritis, colitis or gastritis, persistent or chronic diarrhea of unknown etiology, Clostridium difficile infection (recurrent) or Helicobacter pylori infection (untreated) Age over 80
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analyses Level of TNF-a, IL-1ß, IL-10, Malondialdehyde (MDA), Total antioxidant capacity (TAC). Timepoint: At the beginning of the study and week 12. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehri Salari
Shahid Beheshti University of Medical Sciences
Outcome results
None listed