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Tranexamic acid and uterine atony

Evaluation of the effect of tranexamic acid with oxytocin in controlling bleeding due to uterine atony during cesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200919048762N2
Enrollment
140
Registered
2021-05-30
Start date
2021-01-03
Completion date
Unknown
Last updated
2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

uterine atony. Other uterine inertia

Interventions

Intervention 1: Intervention group: Oxytocin ampoule of 40 units per liter of ringer serum and tranxamic acid ampoule of 1 gram in 10 cc of normal saline serum are given slowly intravenously for 1 min

Sponsors

Yasouj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Existence of uterine atony based on the surgeon's clinical judgment during the operation (bleeding has been more than 1000 cc and bleeding continues with the help of common methods such as uterine massage and oxytocine)

Exclusion criteria

Exclusion criteria: History of coagulation, kidney, liver disease Sensitivity to tranexamic acid Severe preeclampsia Thromboembolism Uncontrolled hypertension History of heart attack or stroke History of accreta and increta placenta Take anticoagulants 24 hours before surgery Take aspirin 7 days before surgery Consumption of omega 3 and garlic

Design outcomes

Primary

MeasureTime frame
Bleeding volume after atony. Timepoint: Immediatly after atony and after intervention. Method of measurement: Per cc and weight of used gazes.

Secondary

MeasureTime frame
Hemoglobin's changes. Timepoint: 6 hours after bleeding. Method of measurement: gr/dl with Spectrophotometer calibrated.;The need for blood products. Timepoint: After intervention until discharge. Method of measurement: based on unit and signs in surgen's examination or Hemoglobin less than 7.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParvin Ghaffari

Yasouj University of Medical Sciences

pari.ghaffari@gmail.com00987431000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026