The effect of surgical hemostat sponge containing aloevera nanoparticles on the amount of pain and occurrence of dry socket

The effect of surgical hemostat sponge containing aloevera nanoparticles on the amount of pain and occurrence of dry socket comparing with commercial geltamp after extraction of mandibular first and second molars.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200919048756N9

Enrollment

Registered

2024-06-08

Start date

2024-05-30

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extraction of the first and second mandibular teeth. Alveolitis of jaws

Interventions

Intervention 1: Intervention group: One of the two first or second mandibular of patients in which the production geltamp (a gelatin sponge containig aleovera nanoparticles) will be placed. How to use

In each patient, after extracting the tooth, a production geltamp will be placed in the extracted tooth cavity. Duration of use: It will remain in the place for at least 4 days and after that, it can

In each patient, after extracting the tooth, a commercial geltamp will be placed in the extracted tooth cavity. Duration of use: It will remain in the place for at least 4 days and after that, it can

Eligibility

Sex/Gender

All

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Need for extraction of two mandibular first molars Age between 20-45 years No corticosteroids and antibiotics using in the last month No acute or uncontrolled infection at the dental surgery site No malignancy at the dental surgery site No contraceptives using at last month No smoking No hypertension, diabetes, thyroid disorders and blood diseases No coagulation disorders

Exclusion criteria

Exclusion criteria: People taking anticoagulants Not signing the consent form Having a systemic disease Patients whose teeth do not come out normally and need surgery and sectioning

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: One, 24, 36 and 48 hours after tooth extraction. Method of measurement: Using a visual analog scale (VAS), which is pre-designed in a special sheet, it will be measured and the patient will indicate his pain level in four time periods from 1 (the least amount of pain) to 10 (the most amount of pain) by making a mark. Next, a special sheet for recording information after tooth extraction and providing necessary training on how to record will be given to the patient and the patient will hand it over after completing the information.;Dry socket occurrence. Timepoint: 4 days after tooth extraction. Method of measurement: 4 days later, the patients come for examination and are examined for the occurrence of dry silent. Clinical examination of the patient and completion of information forms are used to collect information.	—

Measure

Time frame

Pain. Timepoint: One, 24, 36 and 48 hours after tooth extraction. Method of measurement: Using a visual analog scale (VAS), which is pre-designed in a special sheet, it will be measured and the patient will indicate his pain level in four time periods from 1 (the least amount of pain) to 10 (the most amount of pain) by making a mark. Next, a special sheet for recording information after tooth extraction and providing necessary training on how to record will be given to the patient and the patient will hand it over after completing the information.;Dry socket occurrence. Timepoint: 4 days after tooth extraction. Method of measurement: 4 days later, the patients come for examination and are examined for the occurrence of dry silent. Clinical examination of the patient and completion of information forms are used to collect information.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Ali Ghavimi

Tabriz University of Medical Sciences

m_ghavimi@yahoo.com+98 41 3335 3161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026