H. pylori infection. Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention 1: Intervention group: The A group (high dose metronidazole): amoxicillin 1 gr BD, metronidazole 1 gr BD, bismuth 240 mg BD, and pantoprazole 40 mg BD for 14 days. Intervention 2: Interve
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients have H. pylori eradication indication based on endoscopic evidence Patients with positive Rapid urease test Patients with positive histology of H. pylori infection
Exclusion criteria
Exclusion criteria: Age under 18 years Reluctance to participate in the study Pregnancy and lactation Patients taking concomitant anticoagulants, corticosteroids or ketoconazole. Patients with a history of gastric surgery Patients with a history of heart failure, lung disease, chronic kidney failure, liver disease (cirrhosis or chronic hepatitis for any reason), or a history of cancer Consumption of alcohol in any amount The presence of any type of malignancy History of drug allergy to the drugs in this study History of H. pylori eradication regimens at any time before this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradicating. Timepoint: At least the eighth week after starting treatment. Method of measurement: stool examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug compliance rate. Timepoint: 8th week of study. Method of measurement: questionnaire.;Severity of drug side effects. Timepoint: 8th week of study. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactArash Kazemi
Mazandaran University of Medical Sciences
Outcome results
None listed