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The effect of synbiotics in the treatment of patients with halitosis

The effect of probiotics in the treatment of patients with halitosis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200915048726N2
Enrollment
47
Registered
2023-10-05
Start date
2023-10-22
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Halitosis. Halitosis

Interventions

Intervention group: Patients who are eligible to participate in the study will receive a diet of probiotic capsules every 12 hours. Open a Fami Lact capsule of Bio Fermentation Company and dissolve it

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age range from 18 to 60 years Halitosis with an Organoleptic (OLT) score of two and above, which is subjectively determined by the doctor and objectively by the person herself Informed consent

Exclusion criteria

Exclusion criteria: The presence of infection and active inflammation of the nose and pharynx in examination and history History of sensitivity to probiotics The presence of infection and active inflammation of the mouth and teeth in examination and history Advanced renal failure Cirrhosis of the liver The patient's lack of consent to participate or the desire to withdraw from the study Use of immunosuppressive drugs Pregnancy and breastfeeding Use of mouthwash and mouth fresheners during the study Patients with typical symptoms GERD or peptic ulcer Use of antibiotics in the last month Recent surgery

Design outcomes

Primary

MeasureTime frame
Severity of halitosis. Timepoint: before treatment (day zero); Day 15; Day 30 (end of treatment); Day 45 and Day 60. Method of measurement: based on organoleptic score.

Secondary

MeasureTime frame
Side effects. Timepoint: before treatment (day zero); Day 15; Day 30 (end of treatment). Method of measurement: evaluation checklist.;Remission rate. Timepoint: before treatment (day zero); Day 15; Day 30 (end of treatment); Day 45 and Day 60. Method of measurement: based on organoleptic score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArash Kazemi

Mazandaran University of Medical Sciences

arash_6z@yahoo.com+98 11 3337 4977

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026