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Efficacy and safety of Chlorpromazine in the treatment of COVID-19 patients

Evaluation of efficacy and safety of adding Chlorpromazine to Atazanavir/Ritonavir regimen in the treatment of COVID-19 patients, a randomized double-blind clinical trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200913048708N1
Enrollment
60
Registered
2020-10-01
Start date
2020-10-31
Completion date
Unknown
Last updated
2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: Patients with covid 19 infection will receive standard treatment of Atazanavir/Ritonavirdrug 300/100 mg (Razavi Pharmaceutical Institute) once daily in addition to

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: all admitted patients with covid -19 infection based on clinical findings ,PCR or lung CT abnormality consistent with covid-19 spo2 bellow 93 mmHg age above 18 years old

Exclusion criteria

Exclusion criteria: patient rejection history of antipsycotic use history of seizure, dementia and parkinson disease Hx of liver disease Hx of feochromocytoma allergy to phenothiazines drug any drug interaction between patients medicines and chlorpromazine pregnancy and lactation Hx of covid treatments bradycardia < 60 /min multi-organ failure

Design outcomes

Primary

MeasureTime frame
Patients level of Spo2. Timepoint: daily. Method of measurement: puls oximetr.

Secondary

MeasureTime frame
Need to ICU admission. Timepoint: During the study. Method of measurement: Follow up of patient and documentation of the ICU admission.;Days stayed in the Intensive Care Unit. Timepoint: During the study. Method of measurement: Documenting the days stayed in the Intensive Care Unit.;Days stayed in the hospital. Timepoint: At the end of the study. Method of measurement: Documentation of the hospital stay according to patients chart.;Mortality rate. Timepoint: At the end of the study. Method of measurement: Follow up of patients and documentation of the mortality.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEbrahim Salehifar

Mazandaran University of Medical Sciences

Esalehifar52@gmail.com+98 11 3340 6746

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026