Type 2 diabetes mellitus. Type 2 diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group: Consumption material: Ripe pistachio fruit oil
Chemical composition and concentration: a-Pinene (30.1%), Oxygenated monoterpenes (21.2 %), Sesquiterpene hydrocarbons (9.6 %), Bornyl acetate (8.5 %), Camphene (5.7 %), Myrcene (5.4 %), Spathulenol (
Dosage: 1500 mg per day
How to use: orally 500 mg soft gel
500 mg soft gels are produced by Zahravi Pharmaceutical Company after oil extraction from ripe pistachio fruit by cold press method. Intervention 2: Control group: Consumption material: soybean oil
Chemical composition and concentration: palmitic acid (10%), stearic acid (4%), oleic acid (18%), linoleic acid (55%), and linolenic acid (13%)
After purchasing soybean oil, 500 mg soft gels are produced by Zahravi Pharmaceutical Company.
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Having a 2-year history of type 2 diabetes according to the American Diabetes Association criteria Body mass index (BMI) greater than or equal to 25 kg/m2
Exclusion criteria
Exclusion criteria: Pregnancy Lactation Insulin injection People with autoimmune diseases People with gastrointestinal diseases People with liver disease People with kidney disease People with thyroid disease People with cardiovascular disease People with severe respiratory illness such as asthma and chronic bronchitis Consumption of any vitamins, minerals and dietary supplements Alcohol consumption Consumption of plant sterols Consumption of psyllium Consumption of fish oil Existence of allergies to pistachio plant species
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood sugar. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Glucose oxidase assay.;LDL cholesterol. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Direct enzymatic method.;High-sensitivity C-reactive Protein. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Enzyme-Linked Immunosorbent Assay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin A1C. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Enzymatic assay.;Total cholesterol. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Enzymatic assay.;Tumor necrosis factor-alpha. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Enzyme-Linked Immunosorbent Assay.;Interleukin-6. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Enzyme-Linked Immunosorbent Assay.;Interleukin-10. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Enzyme-Linked Immunosorbent Assay.;Malondialdehyde. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Reactivity with thiobarbituric acid.;Total antioxidant capacity. Timepoint: At the beginning of the study (before the intervention) and at the end of the study. Method of measurement: Colorimetric method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Saber
Kermanshah University of Medical Sciences
Outcome results
None listed