Comparison of the effect of tranexamic acid and dexmedetomidine on the amount of bleeding

Comparison of the effect of tranexamic acid and Dexmedetomidine on the amount of bleeding during Spinal posterior fusion surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200910048678N2

Enrollment

Registered

2021-12-18

Start date

2021-12-22

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal posterior fusion. Fusion of spine

Interventions

Intervention 1: Patients in intervention group 2, before surgery and after induction of anesthesia, receive dexmedetomidine (exir pharmacy) with an initial dose of 1µg/kg for 10 minutes and then with

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18-60 years American Society of Anesthesiologists Class (ASA Class) I & II

Exclusion criteria

Exclusion criteria: Drug addiction Liver and kidney failure Diabetes Heart and lung diseases Coagulation disorders History of allergies to study drugs Pregnancy in women Heart disease includes bradycardia, uncontrolled blood pressure, and AV block II & III Acute cerebrovascular conditions

Design outcomes

Primary

Measure	Time frame
The amount of bleeding. Timepoint: During surgery. Method of measurement: Boezaart scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHengameh Vaezi

Zanjan University of Medical Sciences

Hengameh.vaezi88@gmail.com+98 24 3313 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026