Effects of extract of Foeniculum vulgare on patients with polycystic ovary syndrome (PCOS)

Effects of extract of Foeniculum vulgare on serum levels of estrogen, progesterone, LH and FSH hormones and miR-499, BMP15 and GDF9 genes expression in granulosa cells of patients with polycystic ovary syndrome (PCOS)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200908048665N1

Enrollment

Registered

2023-06-01

Start date

2020-10-22

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovary syndrome (PCOS). Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: women with polycystic ovary syndrome (PCOS) treated with fennel extract in the amount of 100 mg twice a day in the form of capsules made by the research group. Inte

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: According to the Adams criteria based on ovarian ultrasound manifestations is to have at least 10 cysts with a diameter of 2-8 mm around the central stroma, densely and in the form of a necklace. Having Rotterdam diagnosis criteria (menstrual cycle disorder, clinical symptoms, and diagnosis of polycystic ovary in ultrasound diagnosed by a radiology specialist and infertility fellowship). BMI between 18-22 Age between 20-35 years

Exclusion criteria

Exclusion criteria: Patients with Cushing's syndrome and weight-induced amenorrhea Pituitary disorders Congenital Adrenal Hyperplasia (CAH) Prolactinoma Thyroid disorders Androgen-secreting tumors Hypertension Chronic kidney disease Alcoholics and smokers Previous miscarriage Infertility in their husbands

Design outcomes

Primary

Measure	Time frame
Serum level of estrogen hormone. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: ELISA test.;Serum levels of progesterone. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: ELISA test.;FSH serum level. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: ELISA test.;LH serum level. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: ELISA test.;The expression level of 499-miR. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: Real time PCR.;BMP15 gene expression. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: Real time PCR.;GDF9 gene expression. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: Real time PCR.	—

Measure

Time frame

Serum level of estrogen hormone. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: ELISA test.;Serum levels of progesterone. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: ELISA test.;FSH serum level. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: ELISA test.;LH serum level. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: ELISA test.;The expression level of 499-miR. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: Real time PCR.;BMP15 gene expression. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: Real time PCR.;GDF9 gene expression. Timepoint: Before starting the study and before IVF in three groups and after the intervention in the experimental group (After taking 45 days of ethanol extract of fennel plant). Method of measurement: Real time PCR.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRojin Ramezani

Sanandaj University of Medical Sciences

Rojin.Ramezani@gmail.com+98 87 3361 1017

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026