Effect of tropicamide 0.5% vs tropicamide 1% on intraocular pressure of diabetic patients

Comparison of the effect of tropicamide 0.5% and tropicamide 1% on intraocular pressure, pupil size, keratometry and anterior chamber parameters in patients with type 1 and type 2 diabetes mellitus

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200829048553N1

Enrollment

210

Registered

2021-05-31

Start date

2021-06-22

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Type 2 diabetes mellitus. Condition 2: Type 1 diabetes mellitus. Type 2 diabetes mellitus Type 1 diabetes mellitus

Interventions

Intervention 1: Intervention group: this group receives tropicamide 0.5% (one drop every 5 minutes for 2 times) drops. Intervention 2: Intervention group: this group receives tropicamide 1% (one drop

Eligibility

Sex/Gender

All

Age

21 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with Diabetes Mellitus type 1 and 2

Exclusion criteria

Exclusion criteria: Proliferative diabetic retinopathy History of cataract surgery severe nuclear and cortical cataract Glaucoma Intraocular pressure (IOP) greater than 21 mmHg Familial history of glaucoma Narrow angle (Van Herick 1, 2) Cup to disc ratio greater than 0.5 Pregnancy Pterygium Corneal ectasia History of keratorefractive surgery Corneal dystrophy Iris disorders Anisocoria Iris neovascularization Use of miotics or mydriatics

Design outcomes

Primary

Measure	Time frame
Intraocular pressure (IOP). Timepoint: Before intervention, 30 minutes after intervention. Method of measurement: Goldmann applanation tonometry.;Pupillary diameter. Timepoint: Before intervention, 30 minutes after intervention. Method of measurement: Scheimpflug camera (Oculus Pentacam); Autorefractokeratometer (TOMEY RC-5000 and Topcon KR-1);.	—

Secondary

Measure	Time frame
Keratometry. Timepoint: Before intervention, 30 minutes after intervention. Method of measurement: Scheimpflug camera (Oculus Pentacam); Autorefractokeratometer (TOMEY RC-5000 and Topcon KR-1);.;Anterior chamber parameters. Timepoint: Before intervention, 30 minutes after intervention. Method of measurement: Scheimpflug camera (Oculus Pentacam).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNavis Elmi Sadr

Semnan University of Medical Sciences

navid.elmi.sadr@gmail.com+98 23 3343 7824

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Sep 19, 2026