The vitamin A supplementation in COVID-19 patients

Effect of vitamin A supplementation on blood inflammatory markers in COVID-19 patient with heart failure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200826048535N1

Enrollment

Registered

2021-08-13

Start date

2020-10-24

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Corona-virus. Condition 2: Cardiovascular disease. Coronavirus infection, unspecified Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Intervention group: Group A: the participant intake 25000 IU vitamin A 4 softgel/week. Intervention 2: Intervention group: Group B. the participant intake vitamin A 2600 IU, 7 softgel/

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: The individual age between 30-70 year The people with history of cardiovascular disease The COVID-19 people with PCR positive or Chest CT scan with ground glass viral pattern

Exclusion criteria

Exclusion criteria: The end stage renal disease people or GFR<60 The people with liver disease Intubate or end stage disease people The people with consumption vitamin A supplement The patients that suffering cancer disease or chemo-radio therapy The hemodialysis patient GFR<20 The people infected to bacterial or fungal disease

Design outcomes

Primary

Measure	Time frame
C-Reactive Protein. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Erythrocyte Sedimentation Rate. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Platelet. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Neutrophil. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;White blood cells. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Lymphocyte. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Lipid profile. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;25-Hydroxy Vitamin D. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Retinol. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Partial Thromboplastin Time. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Prothrombin Time. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: Taking10-15 cc blood from individuals.	—

Measure

Time frame

C-Reactive Protein. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Erythrocyte Sedimentation Rate. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Platelet. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Neutrophil. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;White blood cells. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Lymphocyte. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Lipid profile. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;25-Hydroxy Vitamin D. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Retinol. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Partial Thromboplastin Time. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: By taking10-15 cc blood from individuals.;Prothrombin Time. Timepoint: Before the supplementation and 2 weeks after supplementation. Method of measurement: Taking10-15 cc blood from individuals.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKhadijeh Mirzaei

Tehran University of Medical Sciences

mirzaei_kh@tums.ac.ir+98 21 8895 5569

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026