The effect of the combination of "dimenhydrinate with metoclopramide" and "dimenhydrinate with ondansetron" with "dimenhydrinate alone" in the prevention of nausea and vomiting after the surgery

Comparative study of the combination of "dimenhydrinate with metoclopramide" and "dimenhydrinate with ondansetron" with "dimenhydrinate alone" in the prevention of nausea and vomiting after cataract surgery under local anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N9

Enrollment

160

Registered

2020-10-22

Start date

2020-11-21

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract surgery. Cataract extraction status

Interventions

Intervention 1: Control group: Patients in this group will be given 2 cc of distilled water half an hour before induction of general anesthesia (which includes injections of 1 cc of 1% propofol, 1 µg

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Candidates for cataract surgery American Society of Anesthesiologists (ASA) physical status classification system equal I, II, and III Stability of patients' hemodynamic status

Exclusion criteria

Exclusion criteria: History of motor disease Smoking or addicted patients Patients with allergies to the studied drugs Liver and vestibular disorders Taking anti-nausea drugs in the past 24 hours Prolongation of surgery more than 45 minutes.

Design outcomes

Primary

Measure	Time frame
Severity of nausea. Timepoint: At the time of discharge from recovery and 2 and 4 hours after leaving recovery. Method of measurement: Visual Analogue Scale.;Severity of vomiting. Timepoint: At the time of discharge from recovery and 2 and 4 hours after leaving recovery. Method of measurement: Visual Analogue Scale.;Pain. Timepoint: 1 hour after surgery. Method of measurement: Visual Analogue Scale.;Patient satisfaction. Timepoint: When referring to the ward. Method of measurement: Visual Analogue Scale.	—

Measure

Time frame

Severity of nausea. Timepoint: At the time of discharge from recovery and 2 and 4 hours after leaving recovery. Method of measurement: Visual Analogue Scale.;Severity of vomiting. Timepoint: At the time of discharge from recovery and 2 and 4 hours after leaving recovery. Method of measurement: Visual Analogue Scale.;Pain. Timepoint: 1 hour after surgery. Method of measurement: Visual Analogue Scale.;Patient satisfaction. Timepoint: When referring to the ward. Method of measurement: Visual Analogue Scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMorteza Heidari

Esfahan University of Medical Sciences

m_heidari@med.mui.ac.ir+98 31 3445 2034

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026