Investigation of the relationship between mean arterial blood pressure during cardiopulmonary bypass (CPB) and the incidence of acute kidney injury

Investigating the relationship between mean arterial blood pressure during cardiopulmonary bypass (CPB) and the incidence of acute kidney injury after coronary artery bypass graft surgery in patients with hypertension

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N84

Enrollment

120

Registered

2025-08-17

Start date

2025-08-23

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass graft. Atherosclerosis of coronary artery bypass graft(s) without angina pectoris

Interventions

Intervention 1: First intervention group: In this group, extracorporeal circulation is established with the help of a cardiopulmonary pump device(Stöcker model, Germany) so that the mean arterial bloo

Eligibility

Sex/Gender

All

Age

25 Years to 75 Years

Inclusion criteria

Inclusion criteria: Candidates for elective coronary artery bypass graft surgery Age range 25 to 75 years Having hypertension (Systolic Blood Presure/Diastolic Blood Presure: 140 / 90 mmHg) (without acute organ damage caused by high blood pressure) Eject fraction (EF) more than 40% No carotid artery occlusion (because it can be a contraindication to blood pressure reduction) Consent to participate in the study

Exclusion criteria

Exclusion criteria: Creatinine more than 1.4 mg/dL or glomerular filtration rate (GFR) less than 60 mL/min/1.73 m2 before surgery Previous history of cardiac surgery Presence of endocarditis Presence of liver dysfunction Presence of previous Acute kidney injury (AKI)

Design outcomes

Primary

Measure	Time frame
Serum creatinine. Timepoint: Before surgery, on the first, third and seventh days after surgery. Method of measurement: Paadco creatinine kit.;Estimated Glomerular Filtration Rate (eGFR ). Timepoint: Before surgery, on the first, third and seventh days after surgery. Method of measurement: Based on formula: [175 × Serum Cr ^(-1.154)] × [age ^ (-0.203) × 1.212].;Hemoglobin. Timepoint: Before surgery, on the first, third and seventh days after surgery. Method of measurement: Drabkin hemoglobin kit.;Hematocrit. Timepoint: Before surgery, on the first, third and seventh days after surgery. Method of measurement: Drabkin hematocrit kit.;Acute Kidney Injury. Timepoint: During cardiopulmonary bypass. Method of measurement: Based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria.	—

Measure

Time frame

Serum creatinine. Timepoint: Before surgery, on the first, third and seventh days after surgery. Method of measurement: Paadco creatinine kit.;Estimated Glomerular Filtration Rate (eGFR ). Timepoint: Before surgery, on the first, third and seventh days after surgery. Method of measurement: Based on formula: [175 × Serum Cr ^(-1.154)] × [age ^ (-0.203) × 1.212].;Hemoglobin. Timepoint: Before surgery, on the first, third and seventh days after surgery. Method of measurement: Drabkin hemoglobin kit.;Hematocrit. Timepoint: Before surgery, on the first, third and seventh days after surgery. Method of measurement: Drabkin hematocrit kit.;Acute Kidney Injury. Timepoint: During cardiopulmonary bypass. Method of measurement: Based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahmoud Saeidi

Esfahan University of Medical Sciences

saeidi@med.mui.ac.ir+98 31 3260 0961

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026