Effect of intranasal dexmedetomidine on pain after surgery

Evaluation of the effect of intranasal dexmedetomidine administration on pain reliefon after vitrectomy surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N78

Enrollment

Registered

2024-12-17

Start date

2025-01-20

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitrectomy surgery. Other specified postprocedural states

Interventions

Intervention 1: Intervention group: The patient is under general anesthesia. Immediately after anesthesia, dexmedetomidine (Exir Pharmaceutical Company) is administered as intranasal drops at a dose o

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age group over 18 years Candidate for vitrectomy at Faiz Hospital Informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Addiction to opioid products History of allergy to the study drug

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Visual analog scale (VAS).	—

Secondary

Measure	Time frame
Heart rate. Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Monitoring device.;Blood pressure. Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Monitoring device.;Respiratory Rate. Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Monitoring device.;Oxygen saturation percentage (SPO2). Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Monitoring device.	—

Measure

Time frame

Heart rate. Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Monitoring device.;Blood pressure. Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Monitoring device.;Respiratory Rate. Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Monitoring device.;Oxygen saturation percentage (SPO2). Timepoint: Before the onset of anesthesia, immediately after anesthesia, every 15 minutes during surgery, after surgery every 15 minutes to two hours, and after discharge from recovery every hour to 6 hours. Method of measurement: Monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Hoghooghi

Esfahan University of Medical Sciences

alireza.hoghooghy@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026