Protective effect of Silymarin on liver during cardiac surgery

Protective effect of Silymarin on liver during coronary artery bypass surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N77

Enrollment

Registered

2024-12-15

Start date

2025-01-04

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass surgery. Atherosclerosis of coronary artery bypass graft(s) without angina pectoris

Interventions

Intervention 1: Intervention group: Patients will receive 6 mg/kg of silymarin daily from one week before surgery with the brand name Livergol, manufactured by Gol Daru Company, each tablet containing

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for elective CABG surgery Age between 30 and 70 years EF greater than 40% Written consent to participate in the study

Exclusion criteria

Exclusion criteria: Clinical evidence of active inflammatory or immunomodulatory disease (such as acute coronary syndromes, malignancy, intermittent infections, renal failure, or autoimmune disease (such as hepatitis)) Positive HBV and HCV test results History of anti-inflammatory or antioxidant drugs before surgery History of chronic liver disease Chronic alcohol consumption Patients who are candidates for multiple surgeries at the same time Patients who require emergency surgery Any history of myocardial infarction within the previous 2 months

Design outcomes

Primary

Measure	Time frame
Alkaline Phosphatase (ALP). Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Alanine aminotransferase (ALT). Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Aspartate transaminase (AST). Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Bilirubin. Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Troponin. Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;ESR. Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;C-Reactive Protein (CRP). Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Interleukin-6 (IL-6). Timepoint: Before the intervention, before surgery, immediately after surgery, 6 hours after surgery. Method of measurement: Blood test.	—

Measure

Time frame

Alkaline Phosphatase (ALP). Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Alanine aminotransferase (ALT). Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Aspartate transaminase (AST). Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Bilirubin. Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Troponin. Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;ESR. Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;C-Reactive Protein (CRP). Timepoint: Before the intervention, before surgery, immediately after surgery, 48 hours and one week after surgery. Method of measurement: Blood test.;Interleukin-6 (IL-6). Timepoint: Before the intervention, before surgery, immediately after surgery, 6 hours after surgery. Method of measurement: Blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehran Shahzamani

Esfahan University of Medical Sciences

drshahzamani@yahoo.com+98 31 3260 0961

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026