Evaluation of laboratory findings and clinical outcome of addition of ascorbic acid in patients undergoing coronary artery bypass grafting

Evaluation of laboratory findings and clinical outcome of addition of ascorbic acid in prime fluid in patients undergoing CABG

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N75

Enrollment

110

Registered

2024-10-25

Start date

2024-12-21

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass surgery. Atherosclerosis of coronary artery bypass graft(s) without angina pectoris

Interventions

Intervention 1: Intervention group: 25 mg/kg of ascorbic acid will be added to the prime solution. Intervention 2: Control group: 25 mg/kg placebo (normal saline) will be added to the prime solution.

Eligibility

Sex/Gender

All

Age

35 Years to No maximum

Inclusion criteria

Inclusion criteria: Candidate patients for elective CABG surgery in Chamran Hospital Age category over 35 years EF (ejection fraction) more than 30% Consent to participate in the study

Exclusion criteria

Exclusion criteria: Patients who have other cardiac surgeries at the same time as coronary bypass surgery History of vitamin C consumption in the last three months History of corticosteroid use before hospitalization Severe renal or hepatic failure Re-surgery Having drug sensitivity Having a history of celiac disease (due to the effect on vitamin C levels) or malabsorption problems

Design outcomes

Primary

Measure	Time frame
C reactive protein(CRP). Timepoint: Before and 12 hours after surgery. Method of measurement: Blood test.;Ejection Fraction (EF). Timepoint: Before the intervention, at the time of discharge and two weeks after the surgery. Method of measurement: Echocardiography.;Chest tube drainage rate. Timepoint: After admission to ICU and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Measured in milliliters.;Troponin. Timepoint: Before and 12 hours after surgery. Method of measurement: Blood test.	—

Measure

Time frame

C reactive protein(CRP). Timepoint: Before and 12 hours after surgery. Method of measurement: Blood test.;Ejection Fraction (EF). Timepoint: Before the intervention, at the time of discharge and two weeks after the surgery. Method of measurement: Echocardiography.;Chest tube drainage rate. Timepoint: After admission to ICU and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Measured in milliliters.;Troponin. Timepoint: Before and 12 hours after surgery. Method of measurement: Blood test.

—

Secondary

Measure	Time frame
Serum Glutamic Pyruvic Transaminase (SGPT). Timepoint: Before and 12 hours after surgery. Method of measurement: Blood test.;Serum glutamic-oxaloacetic transaminase (SGOT). Timepoint: Before and 12 hours after surgery. Method of measurement: Blood test.;Lactate dehydrogenase (LDH). Timepoint: Before and 12 hours after surgery. Method of measurement: Blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Hosseini

Esfahan University of Medical Sciences

drhosseiny@yahoo.com+98 31 3260 0961

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026