The effect of two different doses of mannitol on the reduction of creatine phosphokinase in brain death patients

Investigating the effect of two different doses of mannitol on reducing creatine phosphokinase (CPK) in brain death patients planned for organ donation

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N67

Enrollment

Registered

2023-05-18

Start date

2023-06-21

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain death. Brain death

Interventions

Intervention 1: First intervention group: In this group, 0.4 g/kg of mannitol along with 1 mEq of sodium bicarbonate per kilogram will be given in 20 minutes. Intervention 2: The second intervention g

Eligibility

Sex/Gender

All

Age

16 Years to 55 Years

Inclusion criteria

Inclusion criteria: Confirmation of the patient's brain death Having the age of 16 to 55 years Confirmation of the patient's eligibility for kidney donation by the relevant team The presence of creatine phosphokinase greater than or equal to 5000 units per liter in the patient's initial test Consent of the patient's companions to perform the transplant and participate in the study

Exclusion criteria

Exclusion criteria: Having a pacemaker Heart failure Sepsis

Design outcomes

Primary

Measure	Time frame
Creatine phosphokinase. Timepoint: 8 hours after receiving each dose of mannitol. Method of measurement: Blood test.;Creatinine. Timepoint: 8 hours after receiving each dose of mannitol. Method of measurement: Blood test.;Sodium. Timepoint: 8 hours after receiving each dose of mannitol. Method of measurement: Blood test.;Potassium. Timepoint: 8 hours after receiving each dose of mannitol. Method of measurement: Blood test.	—

Measure

Time frame

Creatine phosphokinase. Timepoint: 8 hours after receiving each dose of mannitol. Method of measurement: Blood test.;Creatinine. Timepoint: 8 hours after receiving each dose of mannitol. Method of measurement: Blood test.;Sodium. Timepoint: 8 hours after receiving each dose of mannitol. Method of measurement: Blood test.;Potassium. Timepoint: 8 hours after receiving each dose of mannitol. Method of measurement: Blood test.

—

Secondary

Measure	Time frame
Blood pressure. Timepoint: 2 hours after receiving each dose of mannitol. Method of measurement: Sphygmomanometer.;Heart beat. Timepoint: 2 hours after receiving each dose of mannitol. Method of measurement: Pulse oximeter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParviz Kashefi

Esfahan University of Medical Sciences

Kashefi@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026