The effect of bupivacaine on pain reduction after hysterectomy surgery.

The effect of bupivacaine (Marcaine) intraperitoneal instillation on pain reduction after open hysterectomy surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N66

Enrollment

110

Registered

2023-04-24

Start date

2023-05-21

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hysterectomy surgery.

Interventions

Intervention 1: Intervention group: After surgery, before closing the peritoneum, 40 ml of bupivacaine 0.25% is sprayed into the peritoneal cavity. Intervention 2: Control group: After surgery, before

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Women candidates for hysterectomy surgery Age range from 18 to 65 years Having ASA class one and two No history of allergy to the drugs used (bupivacaine or morphine) Not having an underlying disease (such as asthma, other chronic diseases) Consent to participate in the study

Exclusion criteria

Exclusion criteria: Drug use (having an addiction)

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Monitoring device.;Heart beat. Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Monitoring device.;Oxygen saturation (SPO2). Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Monitoring device.;Severity of pain. Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Visual Analogue Scale.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Monitoring device.;Heart beat. Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Monitoring device.;Oxygen saturation (SPO2). Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Monitoring device.;Severity of pain. Timepoint: Before surgery, immediately after surgery, (in the first hour after surgery, every 15 minutes, in the second hour, every 30 minutes, and then at 8, 6, 4, 3, 2 hours) after surgery. Method of measurement: Visual Analogue Scale.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Hoghooghi

Esfahan University of Medical Sciences

alireza.hoghooghy@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026