The effect of two doses of remifentanil on bleeding rate, intraoperative hemodynamic changes, and complications after rhinoplasty surgery.

Comparison of the effect of infusion of two doses of remifentanil on bleeding rate, intraoperative hemodynamic changes, and complications after rhinoplasty after general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N65

Enrollment

Registered

2023-02-25

Start date

2023-03-06

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinoplasty surgery candidate.

Interventions

Intervention 1: First intervention group: In this group, after general anesthesia, remifentanil (Exir Pharmaceutical Company) infusion is done at a rate of 50-100 micrograms/kg. Intervention 2: Second

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age group 18 to 50 years Candidate for rhinoplasty with class I and II ASA (American Society of Anesthesiologists) Consent to participate in the study

Exclusion criteria

Exclusion criteria: Having a history of previous rhinoplasty Having an allergy to remifentanil Opioid abuse Bleeding disorder Use of contraceptive methods

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before induction of anesthesia, every ten minutes during operation and every ten minutes during recovery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before induction of anesthesia, every ten minutes during operation and every ten minutes during recovery. Method of measurement: Monitoring device.;Heart beat. Timepoint: Before induction of anesthesia, every ten minutes during operation and every ten minutes during recovery. Method of measurement: Monitoring device.;Oxygen saturation (SPO2). Timepoint: Before induction of anesthesia, every ten minutes during operation and every ten minutes during recovery. Method of measurement: Monitoring device.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before induction of anesthesia, every ten minutes during operation and every ten minutes during recovery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before induction of anesthesia, every ten minutes during operation and every ten minutes during recovery. Method of measurement: Monitoring device.;Heart beat. Timepoint: Before induction of anesthesia, every ten minutes during operation and every ten minutes during recovery. Method of measurement: Monitoring device.;Oxygen saturation (SPO2). Timepoint: Before induction of anesthesia, every ten minutes during operation and every ten minutes during recovery. Method of measurement: Monitoring device.

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Secondary

Measure	Time frame
Bleeding volume. Timepoint: During surgery. Method of measurement: Measurement of blood volume in suction.;Tachycardia. Timepoint: After surgery. Method of measurement: Heart rate more than 100 beats per minute.;Bradycardia. Timepoint: After surgery. Method of measurement: Heart rate less than 60 beats per minute.;Nausea and vomiting. Timepoint: After surgery. Method of measurement: Observational.	—

Measure

Time frame

Bleeding volume. Timepoint: During surgery. Method of measurement: Measurement of blood volume in suction.;Tachycardia. Timepoint: After surgery. Method of measurement: Heart rate more than 100 beats per minute.;Bradycardia. Timepoint: After surgery. Method of measurement: Heart rate less than 60 beats per minute.;Nausea and vomiting. Timepoint: After surgery. Method of measurement: Observational.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Shetabi

Esfahan University of Medical Sciences

hamid.shetabi@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026