The effectiveness of vitamin C and thiamine administration method in the improvement and prognosis of shock patients 1 month to 15 years

Investigating the vitamin C and thiamine administration method with the usual method in the improvement and prognosis of shock patients 1 month to 15 years

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N61

Enrollment

270

Registered

2022-10-14

Start date

2022-09-22

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Shock. Shock, unspecified

Interventions

Intervention 1: First intervention group: For patients in this group, vitamin C medicine will be prescribed at a dose of 30 mg/kg every 6 hours up to a maximum of 1500 mg/dose for 4 days or until admi

Eligibility

Sex/Gender

All

Age

1 Months to 15 Years

Inclusion criteria

Inclusion criteria: Children from 1 month to 15 years Suffering from shock (other than obstructive shock) Need vasopressors to maintain at least 5% of blood pressure percentile for age Parents' consent to participate in the study

Exclusion criteria

Exclusion criteria: Having active gastrointestinal bleeding

Design outcomes

Primary

Measure	Time frame
The amount of Vasopressor requirement. Timepoint: During the intervention. Method of measurement: Number of vasopressor injections.;Ventilator requirement. Timepoint: During the intervention. Method of measurement: PaCo2<50% and pH<7.3.	—

Secondary

Measure	Time frame
Blood Creatinine. Timepoint: In the first four days of hospitalization. Method of measurement: Blood test.;C-reactive protein (CRP). Timepoint: In the first four days of hospitalization. Method of measurement: Blood test.;White blood cell. Timepoint: In the first four days of hospitalization. Method of measurement: Blood test.;Lactate. Timepoint: In the first four days of hospitalization. Method of measurement: Blood test.	—

Measure

Time frame

Blood Creatinine. Timepoint: In the first four days of hospitalization. Method of measurement: Blood test.;C-reactive protein (CRP). Timepoint: In the first four days of hospitalization. Method of measurement: Blood test.;White blood cell. Timepoint: In the first four days of hospitalization. Method of measurement: Blood test.;Lactate. Timepoint: In the first four days of hospitalization. Method of measurement: Blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazanin Zibanejad

Esfahan University of Medical Sciences

zibanejadn@gmail.com+98 31 3386 6266

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026