Comparing the effect of "bupivacaine" with "bupivacaine plus dexmedetomidine" in reducing pain after caesarean section.

Comparing the preventive effect of infiltration into the surgical incision "bupivacaine" with "bupivacaine plus dexmedetomidine" in reducing pain after caesarean section.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N60

Enrollment

Registered

2022-09-12

Start date

2022-09-22

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean delivery. Encounter for cesarean delivery without indication

Interventions

Intervention 1: First intervention group: In this group, local subcutaneous wound infiltration of 0.25% bupivacaine (3 mg/kg) diluted with normal saline up to 40 ml will be done. Intervention 2: Secon

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Candidate for caesarean section (for the first time) Elective caesarean section The maximum duration of operation is 90 minutes Performing caesarean section surgery using spinal anesthesia or anesthesia from the back Consent to participate in the study

Exclusion criteria

Exclusion criteria: Uncontrollable underlying disease (ASA3 and higher) Twin pregnancy and above[3] Having a history of allergies to the drugs used (such as bupivacaine, dexmedetomidine) The lack of effect of opioids on them and having acute or chronic pain before surgery

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Immediately after entering the recovery and every half hour to the first two hours and every hour to the second hour after surgery. Method of measurement: Visual analog scale (VAS).;Blood presure. Timepoint: Upon entering the study and every half hour to two hours and every hour to two hours after surgery. Method of measurement: Monitoring device.;Heart rate. Timepoint: Upon entering the study and every half hour to two hours and every hour to two hours after surgery. Method of measurement: Monitoring device.;Oxygen saturation percentage (SPO2). Timepoint: Upon entering the study and every half hour to two hours and every hour to two hours after surgery. Method of measurement: Monitoring device.	—

Measure

Time frame

Pain. Timepoint: Immediately after entering the recovery and every half hour to the first two hours and every hour to the second hour after surgery. Method of measurement: Visual analog scale (VAS).;Blood presure. Timepoint: Upon entering the study and every half hour to two hours and every hour to two hours after surgery. Method of measurement: Monitoring device.;Heart rate. Timepoint: Upon entering the study and every half hour to two hours and every hour to two hours after surgery. Method of measurement: Monitoring device.;Oxygen saturation percentage (SPO2). Timepoint: Upon entering the study and every half hour to two hours and every hour to two hours after surgery. Method of measurement: Monitoring device.

—

Secondary

Measure	Time frame
Nausea. Timepoint: After surgery. Method of measurement: Observational.;Vomiting. Timepoint: After surgery. Method of measurement: Observational.;Chills. Timepoint: After surgery. Method of measurement: Observational.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Hoghooghi

Esfahan University of Medical Sciences

alireza.hoghooghy@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026