Effect of different doses of ketamine on prevention of fentanyl induced coughing

Effect of different doses of ketamine on prevention of fentanyl induced coughing during general anesthesia induction

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N55

Enrollment

Registered

2022-06-21

Start date

2022-07-22

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Candidate patients for surgery under general anesthesia using fentanyl.

Interventions

Intervention 1: Intervention group 1: Patients in this group receive ketamine at a dose of 0.15 mg / kg intravenously within 10 seconds, one minute before fentanyl injection. Intervention 2: Intervent

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age category 65-18 years Candidate for surgery under general anesthesia using fentanyl American Society of Anesthesiologists (ASA) I or II Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Underlying diseases (including heart failure, respiratory, liver, kidney, myocardial ischemic disease, myocardial infarction, hypertension above 140/90 mm Hg, tachycardia (heart rate above 100 beats per minute), depression, asthma, chronic cough) History of allergy to the studied drugs Smoking, addiction Having an upper respiratory infection within the last month Use of drugs such as angiotensin converting enzyme inhibitors (ACEIs), antidepressants (over the past two weeks), and steroids (over the past two weeks) that interfere with the study

Design outcomes

Primary

Measure	Time frame
Intensity of cough. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Fentanyl-Induced Cough Scale (FIC).	—

Secondary

Measure	Time frame
Systolic blood pressure. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Hear rate. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Oxygen saturation (SPO2). Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Hear rate. Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.;Oxygen saturation (SPO2). Timepoint: Every 3 minutes during induction of anesthesia from the time of drug injection until 10 minutes after endotracheal intubation. Method of measurement: Monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzim Honarmand

Esfahan University of Medical Sciences

honarmand@med.mui.a.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026