Evaluation of the effect of administration of two doses of dexmedetomidine in the prevention of chills, pain, nausea and vomiting after gallbladder surgery

Evaluation of the effect of preemptive administration of two doses of dexmedetomidine in the prevention of chills, pain, nausea and vomiting after laparoscopic gallbladder surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N53

Enrollment

Registered

2022-05-13

Start date

2022-05-22

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective surgery.

Interventions

Intervention 1: Intervention group 1: For patients in this group, dexmedetomidine(Elixir Pharmaceutical Company) at a dose of 0.3 ug/kg is injected as a bolus over ten minutes. Intervention 2: Second

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients candidates for laparoscopic cholecystectomy American Anesthesiologists Association (ASA) Classification I and II Age category 65-18 years Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: History of monoamine oxidase inhibitor (MAOI), tricyclic antidepressant (TCA), vasoactive, analgesic, opioid before surgery

Design outcomes

Primary

Measure	Time frame
Chills. Timepoint: Every 15 minutes in recovery and every 6 hours in the ward up to 24 hours after surgery. Method of measurement: Observention.	—

Secondary

Measure	Time frame
Systolic blood pressure. Timepoint: At the start of surgery, every 30 minutes during surgery, every 30 minutes in recovery, and every 6 hours in the ward for up to 24 hours after surgery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: At the start of surgery, every 30 minutes during surgery, every 30 minutes in recovery, and every 6 hours in the ward for up to 24 hours after surgery. Method of measurement: Monitoring device.;Hear rate. Timepoint: At the start of surgery, every 30 minutes during surgery, every 30 minutes in recovery, and every 6 hours in the ward for up to 24 hours after surgery. Method of measurement: Monitoring device.	—

Measure

Time frame

Systolic blood pressure. Timepoint: At the start of surgery, every 30 minutes during surgery, every 30 minutes in recovery, and every 6 hours in the ward for up to 24 hours after surgery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: At the start of surgery, every 30 minutes during surgery, every 30 minutes in recovery, and every 6 hours in the ward for up to 24 hours after surgery. Method of measurement: Monitoring device.;Hear rate. Timepoint: At the start of surgery, every 30 minutes during surgery, every 30 minutes in recovery, and every 6 hours in the ward for up to 24 hours after surgery. Method of measurement: Monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohamadreza Safavi

Esfahan University of Medical Sciences

Mr_safsavi@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026