Comparative study of the effectiveness of "Intraconazole with fluticasone", "Doxycycline with fluticasone", and "Fluticasone spray alone" in the treatment of chronic rhinosinusitis

Comparative study of the effectiveness of "Intraconazole with fluticasone", "Doxycycline with fluticasone", and "Fluticasone spray alone" in the treatment of chronic rhinosinusitis with nasal polyp

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N50

Enrollment

108

Registered

2021-12-26

Start date

2022-01-21

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic rhinosinusitis. Chronic sinusitis

Interventions

Intervention 1: Intervention group 1: Patients in this group will receive doxycycline 100 mg twice a day, along with flomist spray intranasally (one puff per nostril every 12 hours). Intervention 2: I

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 65-15 years Having chronic rhinosinusitis More than 6 months history of chronic rhinosinusitis Do not take medication to control chronic rhinosinusitis in a recent month Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Having diabetes Having endocrine and metabolic diseases Having Immune deficiency diseases Allergy to the studied drugs Incidence of hepatic complications due to intraconazole

Design outcomes

Primary

Measure	Time frame
Symptoms of chronic rhinosinusitis. Timepoint: Before and after the intervention. Method of measurement: Twenty-two-item Sino-Nasal Outcome Test (SNOT-22).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSayed Mostafa Hashemi

Esfahan University of Medical Sciences

mostafa_hashemi@med.mui.ac.ir+98 31 3233 0091

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026