Evaluation of the effect of edible herbal medicine in decreasing mortality and hospitalization of patients with COVID-19.

Evaluation of the effect of edible herbal medicine (containing Colchicum autumnale, Olea Europaea, Nigella sativa, Lavandula angustifolia, Zingiber officinale) in decreasing mortality and hospitalization duration in a severe and critical phase of patients with COVID-19.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N49

Enrollment

150

Registered

2021-12-25

Start date

2022-01-21

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: Patients in this group receive standard treatment. In addition, they will be prescribed 2 one-gram oral capsules every 8 hours. The capsules contain 500 mg of honey

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age range 80-40 years Weight over 50 kg Definite infection with COVID-19 according to diagnostic criteria The acute and critical phase of COVID-19 disease who are admitted to the infectious diseases and intensive care unit. Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Pregnancy Breastfeeding Existence of active ulcers in the gastrointestinal tract Patients taking digoxin Patients who have been hospitalized before the start of the study History of allergies to medicinal plants

Design outcomes

Primary

Measure	Time frame
Need for mechanical ventilation. Timepoint: After the intervention. Method of measurement: Observational.;Duration of hospitalization. Timepoint: After the intervention. Method of measurement: Calculate the number of days.;Need to be admitted to the intensive care unit. Timepoint: After the intervention. Method of measurement: Observational.;Mortality. Timepoint: After the intervention. Method of measurement: Observational.	—

Measure

Time frame

Need for mechanical ventilation. Timepoint: After the intervention. Method of measurement: Observational.;Duration of hospitalization. Timepoint: After the intervention. Method of measurement: Calculate the number of days.;Need to be admitted to the intensive care unit. Timepoint: After the intervention. Method of measurement: Observational.;Mortality. Timepoint: After the intervention. Method of measurement: Observational.

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Secondary

Measure	Time frame
Number of breaths. Timepoint: Before and after the intervention. Method of measurement: Ventilator device.;Heart rate. Timepoint: Before and after the intervention. Method of measurement: Ventilator device.;Percentage of oxygen saturation. Timepoint: Before and after the intervention. Method of measurement: Ventilator device.;Interleukin 6. Timepoint: Before and after the intervention. Method of measurement: Blood test.;Lymphocyte level. Timepoint: Before and after the intervention. Method of measurement: Blood test.;Platelet level. Timepoint: Before and after the intervention. Method of measurement: Blood test.	—

Measure

Time frame

Number of breaths. Timepoint: Before and after the intervention. Method of measurement: Ventilator device.;Heart rate. Timepoint: Before and after the intervention. Method of measurement: Ventilator device.;Percentage of oxygen saturation. Timepoint: Before and after the intervention. Method of measurement: Ventilator device.;Interleukin 6. Timepoint: Before and after the intervention. Method of measurement: Blood test.;Lymphocyte level. Timepoint: Before and after the intervention. Method of measurement: Blood test.;Platelet level. Timepoint: Before and after the intervention. Method of measurement: Blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Ghadiri

Esfahan University of Medical Sciences

drrezaghadiri2@gmail.com+98 31 3263 2377

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026