The efficacy of amitriptyline and melatonin in the treatment of tinnitus

Comparative study of the efficacy of amitriptyline and melatonin in the treatment of tinnitus

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N48

Enrollment

Registered

2021-12-01

Start date

2021-12-22

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tinnitus. Tinnitus

Interventions

Intervention 1: Intervention group 1: In this group, patients will be prescribed 3 mg melatonin tablets (Jalinous Pharmaceutical Company) every night for 6 weeks. Intervention 2: Intervention group 2:

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Ages 18 to 65 Diagnosis of subjective idiopathic tinnitus Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Diagnosis of psychiatric problems Sensitivity to tricyclic antidepressants Engaging in night shift jobs High blood pressure Cardiovascular diseases Consumption of aspirin and salicylate compounds Hypercholesterolemia and hyperlipidemia Hyperthyroidism

Design outcomes

Primary

Measure	Time frame
Severity of tinnitus. Timepoint: Before and after the intervention. Method of measurement: Tinnitus handicap inventory Questionnaire (THI).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Chitsaz

Esfahan University of Medical Sciences

ahmadchitsaz@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026