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Evaluation of the effect of "ketamine-metoclopramide" and "acetaminophen-metoclopramide" on pain intensity after deep vitrectomy operation

Evaluation of the effect of "ketamine-metoclopramide" and "acetaminophen-metoclopramide" on pain intensity after deep vitrectomy operation and comparison with control group

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200825048515N4
Enrollment
96
Registered
2020-10-03
Start date
2020-09-22
Completion date
Unknown
Last updated
2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep vitrectomy operation. Other specified postprocedural states

Interventions

Intervention 1: Intervention group: In the first group prophylaxis with a combination of two drugs ketamine at a dose of 0.1 mg / kg plus Metoclopramide at a dose of 0.15 mg / kg delivered by normal s

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Candidates for vitrectomy operation under general anesthesia Hospitalization of patients after surgery for at least 24 hours Patients ability to communicate with clinicians Patients with anesthesia criteria with ASA I and ASA II surgery duration less than 3 hours and more than 1 hour

Exclusion criteria

Exclusion criteria: Patients with pain syndromes Patients with a history of drug and drug addiction Any uncontrolled systemic disease Psychological and neurological diseases Any allergies to the studied drugs

Design outcomes

Primary

MeasureTime frame
Intensity of pain. Timepoint: Upon entering the recovery, 15 minutes and 30 minutes later,Exit-recovery, then at 4, 8, 16 and 24 hours after surgery. Method of measurement: VAS scoring system.;Nausea. Timepoint: Upon entering the recovery, 15 minutes and 30 minutes later,Exit-recovery, then at 4, 8, 16 and 24 hours after surgery. Method of measurement: VAS scoring system.;Time to extubation. Timepoint: From the time of discontinuation of the anesthetic to the exit of the endotracheal tube. Method of measurement: Patient file.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDaroush Moradi Farsani

Esfahan University of Medical Sciences

baranhoseini56@gmail.com+98 31 3445 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026