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The effectiveness of intra-plaque injection of dexamethasone along with oral tadalafil in patients with Peyronie’s disease and chordee

Evaluation of the effectiveness of intra-plaque injection of dexamethasone along with oral tadalafil in patients with Peyronie’s disease and chordee

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200825048515N31
Enrollment
60
Registered
2021-04-13
Start date
2021-04-20
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peyronie's disease. Induration penis plastica

Interventions

Intervention 1: Control group: In this group, patients will receive intra-plaque injection of verapamil 5 mg (2 cc) (in the form of two one-cc insulin syringes) once a week for 12 weeks. Intervention

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 65 years Chordee degree of less than 45 degrees Ultrasound results confirming the presence of plaque Not being in the active phase of the disease (at least one year) Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Having cardiovascular/brain problems History of neurological disorders Arterial and venous insufficiency (confirmed by color Doppler ultrasound) Having uncontrolled blood pressure or diabetes Continuous consumption of nitrate

Design outcomes

Primary

MeasureTime frame
Size of palpable plaques. Timepoint: Before and after the intervention. Method of measurement: Physical examination.;Number of palpable plaques. Timepoint: Before and after the intervention. Method of measurement: Physical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Kazemi

Esfahan University of Medical Sciences

Rezakazemi6788@gmail.com+98 31 3222 2127

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026