The effects of rapid sequence induction and localized laryngeal recurrent nerve block with fentanyl on hemodynamic changes

Comparative study of the effects of rapid sequence induction(RSI) intubation and localized laryngeal recurrent nerve block with fentanyl on hemodynamic changes in patients with hemodynamic disorders

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200825048515N2

Enrollment

Registered

2020-09-16

Start date

2020-09-22

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic Disorders.

Interventions

Intervention 1: Intervention group: In first group, fentanyl 3 mcg/kg, etomidate 0.3 mg/kg and succinylcholine 1.5 mg/kg will be administered to prevent fasciculation. One minute afterwards, intubatio

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Hemodynamic disorder in the form of arterial systolic pressure drop to less than 90 mm Hg The age of over 18 years old and under 65 years old No contraindications to taking succinylcholine ASA I or II A degree of Malampati between I-IV The Consent of the attendant to participate the patient in the study

Exclusion criteria

Exclusion criteria: Chance of difficult intubation (small chin, large tongue, short neck, etc.) A history of throat or tracheal surgery A history of asthma or allergies The presence of infection at the site of the local block Patients with cardiac respiratory arrest who require intubation by Crush method. Patients with hemodynamic disorders who have a history of taking antihypertensive drugs.

Design outcomes

Primary

Measure	Time frame
Blood Pressure. Timepoint: Before, 5, 10, 20 and 30 minutes after intubation. Method of measurement: Monitoring device.;Respiratory rate. Timepoint: Before, 5, 10, 20 and 30 minutes after intubation. Method of measurement: Monitoring device.;Pulse rate. Timepoint: Before, 5, 10, 20 and 30 minutes after intubation. Method of measurement: Monitoring device.;Oxygen saturation percentage. Timepoint: Before, 5, 10, 20 and 30 minutes after intubation. Method of measurement: Monitoring device.	—

Measure

Time frame

Blood Pressure. Timepoint: Before, 5, 10, 20 and 30 minutes after intubation. Method of measurement: Monitoring device.;Respiratory rate. Timepoint: Before, 5, 10, 20 and 30 minutes after intubation. Method of measurement: Monitoring device.;Pulse rate. Timepoint: Before, 5, 10, 20 and 30 minutes after intubation. Method of measurement: Monitoring device.;Oxygen saturation percentage. Timepoint: Before, 5, 10, 20 and 30 minutes after intubation. Method of measurement: Monitoring device.

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Secondary

Measure	Time frame
Success in endotracheal intubation. Timepoint: After intubation. Method of measurement: Observation.;Incidence of complications. Timepoint: After intubation. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKeihan Golshani

Esfahan University of Medical Sciences

k_golshani@med.mui.ac.ir+98 31 3233 0091

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026