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Comparing the effect of "ketamine-midazolam" with "ketamine-dexmedetomidine" on hemodynamic changes in patients candidate for fiberoptic bronchoscopy

Comparative study of the effect of "ketamine-midazolam" with "ketamine-dexmedetomidine" on sedation, pain, and hemodynamic changes in patients candidate for fiberoptic bronchoscopy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200825048515N13
Enrollment
66
Registered
2020-12-03
Start date
2020-10-22
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchoscopy.

Interventions

Intervention 1: First intervention group: First, for all patients, 2% lidocaine(Caspian-Tamin Company) is sprayed onto the vocal cords. For all patients, nasal oxygen with a flow of 2 liters per minut

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients candidate for bronchoscopy The American Society of Anesthesiologists (ASA) Physical Status Classification equal I or II Being consent to participate in the study

Exclusion criteria

Exclusion criteria: Taking painkillers and opioids 24 hours before surgery Taking beta-blockers before the study Allergy to medications Asthma History of cardiovascular disease History of kidney disease History of liver disease History of chronic respiratory disease History of immunodeficiency Consuming alcohol 24 hours before surgery People with heart block and conduction disorders Having muscle weakness

Design outcomes

Primary

MeasureTime frame
Sedation level. Timepoint: Two minutes after bolus injection. Method of measurement: Ramsay Sedation Scale.;Pain. Timepoint: Immediately, 10, 20 and 30 minutes after consciousness. Method of measurement: Visual Analog Scale (VAS).;Blood pressure. Timepoint: Before the intervention, immediately, 10, 20 and 30 minutes after the intervention. Method of measurement: Monitoring device.;Heart rate. Timepoint: Before the intervention, immediately, 10, 20 and 30 minutes after the intervention. Method of measurement: Monitoring device.;Oxygen saturation percentage (SPO2). Timepoint: Before the intervention, immediately, 10, 20 and 30 minutes after the intervention. Method of measurement: Monitoring device.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehzad Nazemroaya

Esfahan University of Medical Sciences

behzad_nazem@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026