Skip to content

The prophylactic effect of neostigmine and atropin combination on the occurrence of post-dural puncture headache in patients undergoing spinal anesthesia

Comparative study of the prophylactic effect of neostigmine and atropin combination on the occurrence of post-dural puncture headache in patients undergoing spinal anesthesia with control group

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200825048515N11
Enrollment
100
Registered
2020-11-09
Start date
2020-11-21
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lower limb surgery. Unspecified injury of left lower leg, initial encounter

Interventions

Intervention 1: Control group: Patients in this group will be subjected to the spinal block as usual. After confirmation of anesthesia, normal saline is administered intravenously per 10 kg of patient

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patient consent to participate in the study American Anesthesiologists Association Classification I and II Duration of surgery less than 2 hours

Exclusion criteria

Exclusion criteria: Taking anticoagulants Existence of a nerve lesion in the limb/spine Coagulation diseases History of spinal surgery, spinal canal stenosis Conductive disorders of the heart History of migraine headaches Opioid addiction History of malignancy

Design outcomes

Primary

MeasureTime frame
Pain severity. Timepoint: From first day to seven days after surgery. Method of measurement: Visual Analogue Scale (VAS).;Duration of headache. Timepoint: From first day to seven days after surgery. Method of measurement: Counting the number of days suffering from headache.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Golparvar

Esfahan University of Medical Sciences

z.ahmadzade@gmail.com+98 31 3233 0091

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026