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The effect of three types of mouthwash "Colistin and Chlorhexidine", "Tobramycin and Chlorhexidine" and "Chlorhexidine alone" in the prevention of ventilator-associated pneumonia

Comparative study of the effect of three types of mouthwash "Colistin and Chlorhexidine", "Tobramycin and Chlorhexidine" and "Chlorhexidine alone" in the prevention of ventilator-associated pneumonia in ICU patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200825048515N1
Enrollment
96
Registered
2020-09-11
Start date
2020-09-22
Completion date
Unknown
Last updated
2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator associated pneumonia. Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group: Patients in this group will receive 5 cc of a pre-prepared solution containing colistin 20 µg/mL (Darupakhsh company) along with chlorhexidine 0.2%(Darupakhsh comp

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: No damage to the mouth, jaw and face Oral health assessment checklist score 10 and less Clinical score of lung infection less than 6 on arrival The patient should be in the first 24 hours of intubation and should wait at least 72 hours for intubation No immunosuppression due to certain drugs or diseases

Exclusion criteria

Exclusion criteria: Having cancer and diabetes and chronic obstructive pulmonary disease Have a history of broad-spectrum antibiotic therapy in the last 3 months Performing the cardiopulmonary resuscitation process Dissatisfaction of him or his companion to participate in the study

Design outcomes

Primary

MeasureTime frame
Positive culture of endotracheal tube. Timepoint: Before and 5 days after starting treatment. Method of measurement: Laboratory.;Positive oral culture. Timepoint: Before and 5 days after starting treatment. Method of measurement: Laboratory.;Type of microorganisms grown. Timepoint: Before and 5 days after starting treatment. Method of measurement: Laboratory.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeed Abbasi

Esfahan University of Medical Sciences

s_abbasi@med.mui.ac.ir+98 31 3665 1609

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026