Effects of Dexmedetomidine and Propofol in brain injury patients

A comparison on effectiveness of Dexmedetomidine and Propofol on serum level of NSE and S100B in patients with traumatic brain injury

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200824048500N1

Enrollment

Registered

2021-01-25

Start date

2021-02-19

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain patients. Diffuse traumatic brain injury

Interventions

Intervention 1: Intervention group 1: Will receive dexmedetomidine 1 mcg/kg IV for intubation.(precedex , Hospira , US). Intervention 2: Intervention group 2 : Will receive propofol (diprivan , Fresen

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Traumatic Brain Injury patients (TBI) Intubation In ICU Over 18 years old

Exclusion criteria

Exclusion criteria: Massive bleeding Acute or chronic renal failure Acute or active liver disease Rheumatologic disorders or auto-immune disease Acute MI Hypersensitivity to drugs or egg and Soya

Design outcomes

Primary

Measure	Time frame
Neuron Specific Enolase (NSE). Timepoint: Before intervention and 24hr after intervention. Method of measurement: Elisa.	—

Secondary

Measure	Time frame
S100 calcium-binding protein B (S100B). Timepoint: Before intervention and 24hr after intervention. Method of measurement: Elisa.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Feizi

Semnan University of Medical Sciences

fatemefeizi9775@gmail.com+98 21 3624 0902

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026