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The effect of magnesium supplementation in improving depressive symptoms in patients with major depressive disorder treated with antidepressants

The effect of adding magnesium supplement on depressive symptoms in patients with major depressive disorder treated with antidepressants (SSRI

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200823048493N1
Enrollment
48
Registered
2020-10-25
Start date
2019-06-10
Completion date
Unknown
Last updated
2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder. Major depressive disorder, single episode, severe with psychotic features

Interventions

Intervention 1: The intervention group was treated with selective serotonin inhibitors (sertraline, citalopram, fluoxetine and fluoxacin) along with magnesium supplement at a dose of 250 mg per day fo

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with major depression based on DSM-S and according to the diagnosis of a psychiatrist Age over 18 years Having minimum education to read the questionnaire

Exclusion criteria

Exclusion criteria: Neurological disorders Taking alcohol and drug use during the last 6 months Active suicidal thoughts Pregnancy and lactation Mental retardation Liver and kidney failure Receiving monooxidase inhibitors during the last 8 weeks History of seizures Taking magnesium-interfering drugs Presence of uncontrolled diseases such as diabetes and high blood pressure Allergy to antidepressants or magnesium supplements

Design outcomes

Primary

MeasureTime frame
Depression. Timepoint: In weeks 0, 2, 4 6. Method of measurement: Via Beck Depression Inventory.

Secondary

MeasureTime frame
Side effects such as diarrhea. Timepoint: 6 weeks after intervention. Method of measurement: Through questions from the patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSusan Sadeghi

Ahvaz University of Medical Sciences

dr.sadeghi_45@yahoo.com+98 61 3374 3001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026