Continuous infusion of Esmolol in patients undergoing CABG surgery

Comparison study of continuous infusion and bolus of Esmolol on hemodynamic response to laryngoscopy and endotracheal intubation in coronary artery bypass graft patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200822048478N2

Enrollment

Registered

2020-10-04

Start date

2015-07-23

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease. Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Infusion group: 0.5 mg/kg Esmolol is injected within 4 minutes and then the infusion is started at 200 µg/kg/min and continues until endotracheal intubation. 0.9% Nacl is administered

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with ASA 2-4 undergoing elective CABG surgery EF>40%

Exclusion criteria

Exclusion criteria: AV conduction block greater than grade 1 asthma acute MI HR<50 Mallampati score greater than 2 Kidney or liver failure History of allergy or Idiosyncratic reaction to ß-blockers Systolic blood pressure less than 100 mmHg Diastolic blood pressure less than 50 mmHg

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: HR and systolic blood pressure and diastolic blood pressure and mean blood pressure before infusion to induction, during and after induction of anesthesia, at laryngoscopy and endotracheal intubation and every minute for 10 minutes after endotracheal intubation are recorded. Method of measurement: After entering the operating room, patients are monitored by pulse oximeter, electrocardiogram and non-invasive blood pressure.To monitor blood pressure invasively, an intra-arterial catheter is inserted into the left radial artery after local injection of Lidocaine.;Systolic blood pressure. Timepoint: HR and systolic blood pressure and diastolic blood pressure and mean blood pressure before infusion to induction, during and after induction of anesthesia, at laryngoscopy and endotracheal intubation and every minute for 10 minutes after endotracheal intubation are recorded. Method of measurement: After entering the operating room, patients are monitored by pulse oximeter, electrocardiogram and non-invasive blood pressure.To monitor blood pressure invasively, an intra-arterial catheter is inserted into the left radial artery after local injection of Lidocaine.;Diastolic blood pressure. Timepoint: HR and systolic blood pressure and diastolic blood pressure and mean blood pressure before infusion to induction, during and after induction of anesthesia, at laryngoscopy and endotracheal intubation and every minute for 10 minutes after endotracheal intubation are recorded. Method of measurement: After entering the operating room, patients are monitored by pulse oximeter, electrocardiogram and non-invasive blood pressure.To monitor blood pressure invasively, an intra-arterial catheter is inserted into the left radial artery after local injection of Lidocaine.;Mean blood pressure. Timepoint: HR and systolic blood pressure and diastolic blood pressure and mean blood pressure before infusion to induction, during and after induction of anesthesia, at laryngoscopy	—

Measure

Time frame

Heart rate. Timepoint: HR and systolic blood pressure and diastolic blood pressure and mean blood pressure before infusion to induction, during and after induction of anesthesia, at laryngoscopy and endotracheal intubation and every minute for 10 minutes after endotracheal intubation are recorded. Method of measurement: After entering the operating room, patients are monitored by pulse oximeter, electrocardiogram and non-invasive blood pressure.To monitor blood pressure invasively, an intra-arterial catheter is inserted into the left radial artery after local injection of Lidocaine.;Systolic blood pressure. Timepoint: HR and systolic blood pressure and diastolic blood pressure and mean blood pressure before infusion to induction, during and after induction of anesthesia, at laryngoscopy and endotracheal intubation and every minute for 10 minutes after endotracheal intubation are recorded. Method of measurement: After entering the operating room, patients are monitored by pulse oximeter, electrocardiogram and non-invasive blood pressure.To monitor blood pressure invasively, an intra-arterial catheter is inserted into the left radial artery after local injection of Lidocaine.;Diastolic blood pressure. Timepoint: HR and systolic blood pressure and diastolic blood pressure and mean blood pressure before infusion to induction, during and after induction of anesthesia, at laryngoscopy and endotracheal intubation and every minute for 10 minutes after endotracheal intubation are recorded. Method of measurement: After entering the operating room, patients are monitored by pulse oximeter, electrocardiogram and non-invasive blood pressure.To monitor blood pressure invasively, an intra-arterial catheter is inserted into the left radial artery after local injection of Lidocaine.;Mean blood pressure. Timepoint: HR and systolic blood pressure and diastolic blood pressure and mean blood pressure before infusion to induction, during and after induction of anesthesia, at laryngoscopy

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHosein Akbari

Kashan University of Medical Sciences

akbari1350_h@yahoo.com+98 31 5554 0021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026